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Yerevan State University - HEALTH.2012.1.2. Detection, diagnosis and monitoring, HEALTH.2012.2.1.2-3 Preparing for the future research and innovation activities in systems medicine

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Date of filling in 23.08.2011
Organization name Yerevan State University
Organization adress 0025,Armenia,Yerevan,Aleq Manoogian str.1
Department/Unit Microwave Radiophysics chair,faculty of Radiophysics
Contact person Dr. Vitali Kalantaryan, associate professor, PhD
Phone +7-374 93 461 330; +7-374 10 558 606
Fax +7-374 10 554 641
E-Mail vkalantaryan@yandex.ru
Organization type
  • Research
  • Education
Special Programme
Call identifier
Topic number HEALTH.2012.1.2. Detection, diagnosis and monitoring, HEALTH.2012.2.1.2-3 Preparing for the future research and innovation activities in systems medicine
Call Deadline 04.10.2011
Short description of the organization (max 12 lines): The Microwave radiophysics dept. has been organised at radiophysical faculty of Yerevan State University about 35 years ago.At the present time on department are carried out interdisciplinary studies of bioeffects of low intensity (athermal) millimeter range electromagnetic radiation for the application in medical practice for diagnoses and therapy. Results of researches have been presented at the international conferences and published in the Russian and foreign scientific journals.
The department possesses generators of millimeter and centimeter ranges,high-sensitivity radiometers, spectrum analyzers, frequency and power measure devices, femtosecond Terahertz range laser (USA). Head of the department is Academician R. M. Martirosyan, President of the National Academy Sciences of Armenia.
Expertise offered HEALTH.2012.1.2. Detection, diagnosis and monitoring
Preliminary MONITORING of urologic cancer
It is known that process of hemolysis is accompanied by formation methemoglobin (MetHb), i.e. not paramagnetic iron Fe2+ is oxidised to paramagnetic Fe3+ , which gives intensive electronic paramagnetic resonance (EPR) signal. Hence by EPR method it is possible to determine the state of an erythrocyte membrane by MetHb level at hemolysis. It is known that the method of electronic paramagnetic resonance possesses high sensitivity, that gives the possibility to receive the detailed information on structure and concentration as paramagnetic proteins of plasma of blood,as and methemoglobin MetHb. At presence urologic pathologies concentration MetHb at hemolysis within the first hour incubation essentially increases (in tens times), that testifies to considerable change of permeability of erythrocyte membrane at an initial stage of development of a tumour. Therefore EPR method can be perspective for preliminary monitoring of urologic cancer patients at early stages of development of a tumour.
Researchers of our department have a wide experience of work with EPR spectrometers, therefore we search partners in theme HEALTH-2012-1.2-Detection , Diagnostics and MONITORING.
HEALTH.2012.2.1.2-3 Preparing for the future research and innovation activities in systems medicine
Non-ionizing and non-invasive potential method for treatment of tumors (Electromagnetic Fields and Health)
Unlike ionizing X- and Gamma-rays, the influence of low-intensity millimeter range electromagnetic radiation on tumors is non-ionizing and non invasive and hence is completely deprived of any harmful side effects opposed to the widely used X-rays or Gamma-rays therapy. Hypermethylation of tumor-DNA may cause the selective sensitivity of malignant cells toward the influence of MMWs in the absence of chemo- and radiotherapy and to allow receiving of expressed antitumor effect.Our studies revealed the correlation of antitumor activity of MM-therapy with inhibition of methylation of tumor DNA in vivo without cytostatic agents. It is mean that low-level electromagnetic fields of millimeter range may modify cancer cell growth and may have a therapeutic effect. Our result indicates the prospects of working out the MM-therapy for clinical oncology in the treatment of malignant neoplasms.The exciting results from this study provide a strong rationale to study the mechanism of action of millimeter waves, which may lead to the discovery of novel pathways controlling tumor grownh. It is needed to clarify all the biochemical effects indused by MMW on cellular systems. These preliminary results open a very interesting research direction which is linked to the possible use of low power MMW radiation against tumor cells, without damaging other tissues. We search partners in theme HEALTH.2012.2.1.2-3. Preparing for the future research and innovation activities in systems medicine.
Scientific keywords Diagnostic and therapy of cancer Non-ionizing radiation Low intensity electromagnetic fields Suppress tumor cells growth Tumor DNA
Publications on the topic (other references)
  • V. Kalantaryan, R. Martirosyan, L. Nersesyan, A.Aharonyan, I. Danielyan,H. Stepanyan, J. Gharibyan, N. Khudaverdyan EFFECT ON TUMORAL CELLS OF LOW INTENSITY ELECTROMAGNETIC WAVES. Progress In Electromagnetics Research Letters, 2011,vol.20,p.98-105.
  • H.Torgomyan,V. Kalantaryan, A. Trchounian. Low Intensity Electromagnetic Irradiation with 70.6 and 73 GHz Frequencies Affects Escherichia coli Growth and Changes Water Properties. Cell Biochemestry & Biophysics, 2011,60,275-281, Online First, DOI: 10.1007/s12013-010-9150-8
  • V. Kalantaryan, P. Vardevanyan, Y. Babayan, E. Gevorgyan, S. Hakobyan, A. Antonyan. Influence of low intensity coherent electromagnetic millimeter radiation (EMR) on aqua solution of DNA. Progress In Electromagnetics Research Letters, 2010,vol.13,p.1-9 .
  • H.Tadevosyan, V. Kalantaryan, A. Trchounian. Extremely High Frequency Electromagnetic Radiation Enforces Bacterial Effects of Inhibitors and Antiobiotics. Cell Biochemestry & Biophysics, 2008, 51(2-3), 97-103,July
  • S. Minasyan, G. Grigoryan, S.Saakyan, A. Akhumyan, V. Kalantaryan. Effects of the Action of Microwave-Frequency Electromagnetic Radiation on the Spike Activity of Neurons in the Supraoptic Nucleus of the Hypothalamus in Rats.-Neuroscience and Behavioral Physiology (USA), 2007, vol.37, N 2, pp.175-180.
  • H.Tadevosyan, V. Kalantaryan, A. Trchounian. Influence of Low Intensity Millimeter Range Coherent Electromagnetic Radiation on E.coli Growth Rate and Role of pH of Environment.Biophysica, 2007, v.52, N 5,p.893-898
  • Yu. Babayan , V. Kalantaryan, R. Kazaryan, P. Vardevanyan, A. Markaryan, M. Parsadanyan. Effect of Low-Energy Microwaves on DNA Stability in Solution. Biophysics, 2007, vol. 52, Number 2, p 259.
  • S. Minasyan, G. Grigoryan, S. Saakyan, A. Hakhumyan, V. Kalantaryan. Effects of Combine Action of Electromagnetic Radiation and Vibration on the Activity of Neurons in the Supraoptic Nucleus of the Hypothalamus. Biomeditsinkie tehnologii i radioelectronica (Biomedical Technologies and Radioelectronics),2006,N5-6,p70-76
  • H. Hovhanisyan, V.Kalantaryan, A. Hakhoumyan, S. Minasyan, K. Hovhanesyan. Blood Catalase Activity Change under Influence of Microwave-Frequency Electromagnetic Radiation. Biomeditsinkie tehnologii i radioelectronica (Biomedical Technologies and Radioelectronics) 2005, N8, p.66-69.
  • V. Kalantaryan, Y. Babayan, A. Tadevosyan. Investigation of the binding of antitumor compouds of Mitoxantrone and Amentantrone with the DNA-irradiated millimeter electromagnetic waves. Abstracts Book, UICC World Cancer Congress, 27-31 August 2008, Geneva, Switzerland, p.82 (POS- A288)
Description of previous and present experience in International Cooperation -
Previous participation in EU’s Framework Programme projects