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Voronezh State University
- HEALTH.2010.2.4.2-2: New approaches to reduce ischemic damage to the heart
Date of filling in
Voronezh State University
1 Universitetskaya sq. 394006 Voronezh, Russian Federation
Biology and Soil Science Faculty, Medical Biochemistry and Microbiology Department
Dr. Larissa Matasova
HEALTH.2010.2.4.2-2: New approaches to reduce ischemic damage to the heart
Short description of the organization (max 12 lines):
The Voronezh State University (VSU) was established on the base of Yuryev University evacuated in Voronezh in 1918. Yuryev (primary – Derpt) University, founded in 1802 by the decree of the Russian emperor Alexander I in Derpt (later - Yuryev, nowadays Tartu), was the second Russian university. The University became the center of education, sciences and culture of Central Chernozem region and continues to carry out these functions now. Now the training of the students in Voronezh State University has been carried out at 17 faculties. The graduates of the University work in 90 countries of the world. The Department of Medical Biochemistry and Microbiology was open at VSU Biology and Soil Science Faculty in 1997. Working group of the Department (more than 10 people, from them 8 have scientific degrees) owns wide experience of work in the field of research of cell metabolism organization and regulation, enzymology. The results of the Department employees investigations lately have found the reflection in 12 candidate dissertations, tens publications in the central journals, materials of the International and Russian conferences on biological and medical subjects. The research work, spent on the Department, repeatedly was supported by the Russian and International grants.
Our team can bring contribution on the decision of biochemistry fundamental problem connected to research of functioning of antioxidant system (АОS) and oxidative metabolism enzymes, capable to limit free-radical oxidation (FRО), at pathologies, connected with oxidative stress (experimental models of myocardium ischemia at rats), and also at action of substances-protectors (thioctic acid, citrate, melatonin and several synthetic substances, received at Voronezh State University Chemical Faculty). Estimation of free-radical processes intensity in analysed tissue is realised by biochemiluminescence method, giving the integral characteristic of a FRO level, definition of the contents of lipid peroxidation primary products – diene conjugates, and DNA fragmentation as index of apoptosis development degree. Activity of AOS enzymes (superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase) and level of some antioxidants (-tocopherol, citrate, glutathione) in myocardium and blood serum at pathology and protectors action are investigated. The research of aconitase, citrate synthase, NAD- and NADP-isocitrate dehydrogenases, NAD- and NADP-malate dehydrogenases, glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase functioning with application of purified enzyme preparations is also spent. The research of these enzymes expression regulation is realized. The reception of the information about properties of the enzymes capable to participate in a FRО intensity regulation in an organism by interaction, will allow to come nearer to comprehension of new aspects of antioxidant system enzymatic and not enzymatic components activity linking and regulation in mammals tissues at pathologies connected with oxidative stress development, and action of substances - protectors. The investigation of biochemical bases of reactive oxygen species formation regulation with the help of substances-protectors promotes clarification of molecular mechanisms of FRO intensity increase, which is a universal non-specific link in various diseases pathogenesis, prevention.
Ischemia of myocardium Free-radical oxidation Antioxidant defense Oxidative metabolism enzymes Substances-cardioprotectors
Publications on the topic (other references)
Medvedeva L.V., Popova T.N., Artyukhov V.G., Matasova L.V. Catalytic and regulatory properties of cytoplasmic and mitochondrial aconitate hydratase of rat cardiomyocytes // Izvestiya RAN. Biology Series. - 2002. - № 5. - P.538-543.
Medvedeva L.V., Popova T.N., Artyukhov V.G., Matasova L.V., Akatova R.V. Oxidative status and distribution of the activity of NADP-isocitrate dehydrogenase and aconitate hydratase in cardiomyocytes of rats at normal conditions and ischemia // // Bull. Exp. Biol. and Med. - 2002 .- V. 134, № 8 .- P. 151-156.
Medvedeva L.V., Popova T.N., Artyukhov V.G., Matasova L.V., Pinheiro de Carvalho M.A.A. The intensity of free radical processes and regulation of the activity of cytoplasmic NADP-isocitrate dehydrogenase in rat cardiomyocytes at norm and ischemia // Biochemistry (Moscow). - 2002. - T. 67, № 6. – S. 838-849.
O.A. Safonova, T.N. Popova, V.G. Artyukhov, L.V. Matasova. Cytoplasmic NAD-malate dehydrogenase functioning peculiarities in rat myocardium at ischemia conditions // Bull. Exp. Biol. and Med. (Moscow). – 2005. - V. 140, No. 7. – P. 31-34.
O.A. Safonova, T.N. Popova, V.G. Artyukhov, L.V. Matasova. Free radical oxidation intensity and regulation of NADP-dependent malate dehydrogenase activity in rat cardiomyocytes in norm and under ischemia // Biomed. Chemistry (Moscow). – 2005. – V. 51, No. 3. – P. 311-321.
O.A. Safonova, T.N. Popova, V.G. Artyukhov, L.V. Matasova. Oxidative status and functioning of NAD-dependent malate dehydrogenase in mitochondria of rat cardiomyocytes in norm and under ischemia // Voprosi Biological, Medical and Pharmaceutical Chemistry (Moscow). – 2005. – No. 1. – P. 50-53.
T. Popova, M.A.A. Pinheiro de Carvalho, L. Matasova, L. Medvedeva. Regulation of mitochondrial NADP-isocitrate dehydrogenase in rat heart during ischemia // Mol. and Cell. Biochem. - 2007. – Vol. 294. – P. 97-105.
Makeeva A.V., Popova T.N., Artyukhov V.G. Changes in the activity of glutathione system and some of the NADPH-generating enzymes under the influence of tioktic acid in myocardial ischemia in rats // Voprosi Biological, Medical and Pharmaceutical Chemistry (Moscow). - 2007. - № 3. - P. 54-56.
Makeeva A.V., Popova T.N., Matasova L.V., Yama I.N. Effects of lipoic acid on citrate content, aconitate hydratase activity, and oxidative status during myocardial ischemia in rats // Biochemistry (Mosc). - 2008. - V. 73(1). – P. 76-79.
Matasova L.V., Popova T.N. Aconitate hydratase of mammals under oxidative stress // Biochemistry (Mosc). – 2008. – V. 73(9). – P. 957-964.
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