RIC
Regional Information Centre
for Scientific and Technological Cooperation with EU
 

FP7 Partner offer profile

Design Technological Institute of Digital Techniques SB RAS - ICT-2011 9.6: FET Proactive: Unconventional Computation (UCOMP), ICT-2011 9.11: FET Proactive: Neuro-Bio-Inspired Systems (NBIS), HEALTH.2012.2.2.2-1 Integrativesystems biology and comparative genomics for studying human ageing and/or most common age-related diseases

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Date of filling in 11.08.2011
Organization name Design Technological Institute of Digital Techniques SB RAS
Organization adress 630090, Russia 6, Acad. Rzhanova Str, Novosibirsk
Department/Unit Laboratory Biomedical Informatics, BioNeuroInformation science
Contact person Prof., Aleksander Ratushnyak, Chief of laboratory
Phone +7-383-3308918
Fax +7-383-3309361
E-Mail ratushniak.alex@gmail.com
ratush@kti.nsc.ru
Web-site http://www.kti.nsc.ru/
Organization type
  • Consultancy
  • Research
Special Programme
Theme
Information and Communication Technologies (ICT)
Health
Call identifier
FP7-ICT-2011-C
FP7-HEALTH-2012-INNOVATION-1
Topic number ICT-2011 9.6: FET Proactive: Unconventional Computation (UCOMP), ICT-2011 9.11: FET Proactive: Neuro-Bio-Inspired Systems (NBIS), HEALTH.2012.2.2.2-1 Integrativesystems biology and comparative genomics for studying human ageing and/or most common age-related diseases
Call Deadline 15.09.2012, 04.10.2011
Short description of the organization (max 12 lines): Design Technological Institute of Digital Techniques of Siberian branch of Russian Academy of Sciences (DTI DT SB RAS) is established by the decree of Presidium SB АS USSR № 493 from October, 16th, 1990 on the basis of special design bureau of computer facilities SB АS USSR, created in 1981. In 2007 according to the decree of Presidium of the Russian Academy of Sciences № 274 from December, 18th, 2007 the Institute is renamed into Institutions of the Russian Academy of Sciences Design Technological Institute of Digital Techniques of Siberian branch of Russian Academy of Sciences.
The scientifically-methodical management of Institute carries out Branch nanotechnology and information technology of the Russian Academy of Sciences. Coordination of scientific researches spent by Institute is carried out by the Joint academic council of the Siberian Branch of the Russian Academy of Science on nanotechnology and to information technologies. Coordination of scientific researches in range neuro and biocomputer science is carried out by the Joint academic council of the Siberian Branch of the Russian Academy of Science on biological sciences.
Expertise offered The main researches in our laboratory are directed to theoretical and experimental analysis of biological neural systems on purpose to develop technical, cognitive systems and restoration of neurologic infringements. On the basis of the received data is formulated and experimentally substantiated the conceptual model of a neuron as molecular, information system that capable recognize, classify and to act on the basis of genetically determined, motivational programs and learning.
Studying of neurons and neural systems in vitro as prototypes of cognitive systems with an artificial intellect is offered. Theoretical and experimental analysis of principles and algorithms of functioning of neural systems, creating of databases and knowledge of molecular mechanisms of realization of information functions by the nerve cells, development of tool means of registration in simple neural systems and brain-computer interface on base of nanotechnology will be carried out. The multi-parametric approach based on a combination of imaging and electrophysiological techniques (including: light, fluorescent, and confocal microscopy, technique microelectrodes, patchclamp, multielectrode arrays); techniques of bioinformatics; models of pathological conditions (oxidative stress, hypoxic-ischemic injury, epileptiform reactions, depressive-like states); models learning and memory (posttetanic potentiation and depression in the cells, the neural networks in tissue culture and hippocampal slices) developed complexes will be used for creating of models of cognitive systems and preclinical testing of pharmacologically promising compounds.
The cultivated neurons and simple neural systems (reconstructed in culture neural networks, hippocampal slices) are used as biosensors for the analysis of the effects of bioactive compounds and various physical and chemical influences.
Scientific keywords NeuroBioInformatics neuron in vitro information properties of a neuron cognitive systems nanotechnological brain-computer interface
Publications on the topic (other references)
  • Zapara T.A,. Simonova O.G, Zharkikh A.A., Balestrino M, Ratushniak A.S. “Seasonal differences and protection by creatine or arginine pretreatment in ischemia of mammalian and molluscan neurons in vitro” Brain Research 1015, 41-49, 2004.
  • Zapara T.A., Simonova O.G., Ratushnyak A.S., Epstein O.I., Shtark M.B. “Plasticity of neuronal responses induced by low concentrations of exogenous ligands affection cellular calcium stores” Frontiers in Bioscience 9, 809-815, 2004.
  • Tolstikova T.G., Bryzgalov A.O., Sorokina I.V., Hvostov M.V., Ratushnyak A.S., Zapara T.A., Simonova O.G. Increase in pharmacological activity of drugs in their clathrates with plant glycosides. // Letters Drug Design Discovery, 2007, 4, 168-170.
  • Tolstikova T.G., Bryzgalov A.O., Sorokina I.V., Ratushnyak A.S., Zapara T.A., Simonova O.G., Tolstikov G.A. To the nature of the effect of glycosidic clathration of pharmacons // Dokl. Biol. Sci. 2007. V. 416, p. 336-337.
  • Bagayev S.N., Zakharov V.N., Orlov V.A., Panov S.V., Ratushnyak A.S., Zapara T.A. Regulation of the Transcapillary Exchange By Pulse Pressure blood // Russian J. Biomechanics, 2008, V. 3, no. 41, p.7-14.
  • Ratushnyak A.S., Zapara T.A. Principles of celluar-molecular mechanisms in neuron functions // J. Integrative Neurosci, 2009.V. 8, No. 4, p. 453–469.
  • Zapara TA, Proskura AL, Ratushnyak AS, Shtark MB, Epstein OI. Substances in subthreshold concentrations under stress conditions can act as conditioned stimuli and trigger defense reactions // Bull. Exp. Biol. Med. 2009. V. 147, no. 1, p. 42-44.
  • Ol'shevskaia J.S, Kozlov A.S, Petrov A.K, Zapara T.A, Ratushniak A.S. Influence of terahertz (submillimeter) laser radiation on neurons in vitro. // Zh Vyssh. Nerv. Deiat. Im I. P. Pavlova. 2009, № 59(3). P. 353-359.
  • Mischenko N.P, Fedoreev S.A, Zapara T.A, Ratushnyak A.S. Effects of histochrom and emoxypin on biophysical properties of electroexitable cells // Bull. Exp. Biol. Med. 2009. № 147 P. 196-200.
  • Proskura A.L., Malahin I.A., Zapara T.A., Ratushnyak A.S. Functions and molecular mechanisms of plastic responses in neural systems. // In coll. Papers conference: Neurocomputer science-2011, М., p. 29-39.
Description of previous and present experience in International Cooperation The laboratory has participated and participates in research programs of cognitive properties of neurons and simple neural systems, developing of methodology of experiments, models of learning and pathological conditions, testing on these models of drugs affecting on cognitive processes and pharmacologically perspective compounds. Cellular and molecular mechanisms of processes functional neuronal plasticity are developing. The knowledge base and the given molecular processes underlying cognitive reactions are creating.
EU's Framework Progremme projects:
FP6 INTAS: Number 00-00 441- Development of new creatine-derived drugs with potent capability of increasing cerebral high-energy stores: A novel approach for prevention and treatment of brain ischemia and stroke. To determine the capability of new synthetic Cr-derived compounds to increase cerebral high-energy store at different routes of administration in in vitro and in vivo experiments.
Previous participation in EU’s Framework Programme projects