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FP7 Partner offer profile

“CSB Genomix” Llc - HEALTH.2012.1.2-1: Development of technologies with a view to patient group stratification for personalised medicine applications, HEALTH.2012.2.1.2-1: Systems medicine: SME-driven research applying systems biology approaches to address medical and clinical needs

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Date of filling in 11.08.2011
Organization name “CSB Genomix” Llc
Organization adress 630090, Russia 8, Lavrentiev ave., Novosibirsk
Department/Unit -
Contact person Mr. Vladislav Mileiko, CEO
Phone +7-9039384550
Fax
E-Mail
Web-site
Organization type
  • SME
  • Research
Special Programme
Theme
Health
Call identifier
FP7-HEALTH-2012-INNOVATION-1
Topic number HEALTH.2012.1.2-1: Development of technologies with a view to patient group stratification for personalised medicine applications, HEALTH.2012.2.1.2-1: Systems medicine: SME-driven research applying systems biology approaches to address medical and clinical needs
Call Deadline 04.10.2011
Short description of the organization (max 12 lines): CSB Genomix team including 4 PhD has great experience of academic and applied research in the field of molecular and cell biology. The key direction of research is investigation of circulating DNA/RNA in humans and tissue culture models.
CSB Genomics has worked out unique technology of obtaining and analysis of circulating DNA adsorbed to blood cells surface (Cell-Surface Bound, CSB). This approach allows to get up to 10-100 times more diagnostic material from conventional blood sample, and to deal with much more intact DNA.
Preliminary retrospective trials shows that circulating DNA bound to blood cells surface, can be used for sensitive detection of tumor DNA-markers and early fetal sex determination.
Expertise offered CSB Genomix have advanced facilities for R&D in the field of in vitro cancer diagnostics and DNA analysis including such systems biology techniques as massive parallel sequencing (SOLiD, Roche 454, Ion Torrent) of epigenome and metagenome.
CSB Genomix`s patented methods of DNA isolation and analysis can serve as a platform for development and optimization of test-sistems (test-kits) for non-invasive diagnostics performing high sensitivity and specificity.
Scientific keywords Early diagnostics Circulating DNA Breast cancer Aberrant methylation Massive parallel sequencing
Publications on the topic (other references)
  • • Skvortsova TE, et al., Cell-free and cell-bound circulating DNA in breast tumours: DNA quantification and analysis of tumour-related gene methylation. 2006, British journal of cancer
  • • Rykova E.Yu., et al. Concentrations of circulating RNA from healthy donors and cancer patients estimated by different methods. 2006, Annals of New-York Academy of Science
  • Vainer O.B., et al. A new Y chromosome marker for noninvasive fetal gender determination. 2008, Annals of the New York Academy of Sciences
  • Tamkovich S.N. et al. 2005. Circulating nucleic acids in blood of healthy male and female donors.Clinical Chemistry
  • Vlassov VV, Laktionov PP, Rykova EY. Circulating nucleic acids as a potential source for cancer biomarkers. 2010, Current Molecular Medicine
  • Patent RU2249820 «Method for early diagnostics of diseases associated with aberrations in genetic apparatus functioning »
  • Patent RU 2251696 «Method for early diagnostics and monitoring of tumors»
  • Patent EP1658384 «Method for early detection and monitoring of diseases by analysis of cell surface-bound nucleic acids»
Description of previous and present experience in International Cooperation Research supported by international program of Civilian R&D Foundation (USA) grant of BRHE Fellowship competition 2006,Y4-B-0813
Previous participation in EU’s Framework Programme projects