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Udmurt State University
- HEALTH.2012.2.3.2-3: Prevention and treatment for HIV/AIDS, malaria and tuberculosis
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Udmurt State University
Universitetskaya st. 1, Izhevsk, Russia, 426034
Immunology and Cell Biology Department
Menshikov Igor V., Ph. D., Head of Immunology and Cell Biology Department, Professor of Biology
HEALTH.2012.2.3.2-3: Prevention and treatment for HIV/AIDS, malaria and tuberculosis
Short description of the organization (max 12 lines):
The Udmurt State University is one of the biggest higher education institutions. More than 75 years the university has made an important contribution to social and economical branch of Udmurtia Republic. It cooperates with Russian science academies and other higher education institutions. It deals with education process organization, researching work, developing international relationships, making wide net of telecommunication through earth and satellite channels etc. The university together with plants, ministries and institutions are occupied with building up industrial branch of medical biotechnology. There are trained specialists for oil branch — oilmen and geologists, specialists for emergency control, ecology ministries, for all spheres of education, science, culture, sport, economy and law system. Research interests of Immunology and Cell Biology Department are: theoretical (mathematical modeling) and experimental researches of the idiotypic network; the Role of idiotype–antiidiotypic interactions in induction and development of autoimmune and oncologic diseases; autoimmunity in atherosclerosis.
The difficulties in developing HIV vaccine and ineffective antivirus therapy gives evidence of considering HIV infection as an extraordinary infectious disease. Present experimental evidence indicates that immunodeficiency during HIV infection is of autoimmune nature. Taking into account the fact of idiotype-anti-idiotipic interactions between anti-gp120 antibodies and anti-CD4+ autoantibodies, one can assume that gp120 proteins serve as inductor of autoimmune reaction against CD4+ lymphocytes via idiotipic interactions. This fact is the foundation on which we can suppose that effective approach for HIV infection treating could be selective suppression of anti-gp120 immune response, which abolish induction of autoimmune reaction against CD4+ cells. Antibodies against other virus antigens, for example gag, can control of virus. There are facts to prove our hypothesis: elite controllers of HIV infection have low level of anti-gp120 antibodies. The aim of the project is to work out the method of suppression anti-gp120 immune response and to study the influence of premises suppression on the autoimmune reaction against CD4+ lymphocytes. At the first stage it is necessary to select antigens inducing anti-CD4+ cell autoimmunity in animals. At the second stage the method of selective suppression of immune response against antigen inductor of anti-CD4 autoantibodies is to be worked out.
Mechanisms of immune regulation Idiotypic immune network Autoimmune reactions Experimental model of autoimmune disease AIDS
Publications on the topic (other references)
Beduleva L, Menshikov I. Role of idiotype-anti-idiotype interactions in the induction of collagen-induced arthritis in rats. Immunobiology. – 2010. - № 12, Vol 215. – P. 963–970.
Menshikov I, Beduleva L, Evidence in favor of a role of idiotypic network in autoimmune hemolytic anemia induction: theoretical and experimental studies. International Immunology 2008; 20:193–8.
Menshikov I, Beduleva L. Use of Fc fragments of class G immunoglobulin as an antigen for treating rheumatoid arthritis, agent and method of treatment. Patent. № 2385164. WO 2010/036146.
Beduleva L, Men'shikov I. Network theory in autoimmunity Usp Fiziol Nauk. (in Russian) 2008; 39: 55-67. Review.
Menshikov I, Beduleva L. Idiotype-anti-idiotype interactions in AIDS syndrome pathogenesis. Immunology (in Russian) 2006; 5:316-21.
Menshikov I, Ivanov V, Bovin V. Mathematical model of antiidiotypic interactions in immune network. Immunology (in Russian) 2004; 5:275-9.
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